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KMID : 1234920150150010024
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Journal of Korean Oriental Association for Study of Obesity
2015 Volume.15 No. 1 p.24 ~ p.32
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Effect of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Agrobacterium Rhizogenes and Coptidis Rhizoma Extracts Combined with Metformin on the Antioxidant and Adipocyte Differentiate Inhibition
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Chang Se-Ju
Han Kyung-Sun
Wang Jing-Hua
Chae Hee-Sung
Choi Young-Hee
Chin Young-Won
Choi Han-Seok
Kim Ho-Jun
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Abstract
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Objectives: This study was to investigate the antioxiative capacity, antiobesity effects of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Agrobacterium Rhizogenes, and Coptidis Rhizoma on Raw 264.7 and 3T3-L1 cell lines.
Methods: Three different types of herb extracts (A. Rhizoma Alba, H. Herba, L. Flos, A. Rhizogenes, and C. Rhizoma; water 100%, ethanol 30%, ethanol 100%) were used in this study. Total polyphenol compound, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reactive oxygen species (ROS) activity, NO production and cell proliferation were measured.
Results: Total polyphenol compound measurement of L. Flos, A. Rhizogenes, and C. Rhizoma extracts were higher than A. Rhizoma Alba, H. Herba. DPPH radical scavenging activity, ROS activity and NO production of A. Rhizogenes, C. Rhizoma extracts were lower than L. Flos, A. Rhizoma, and H. Herba.
Conclusions: Metformin and A. Rhizogenes, C. Rhizoma, A. Rhizoma Alba, and L. Flos extracts combination groups showed synergistic effect on adipocyte differentiation inhibition and antioxidative activity.
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KEYWORD
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Metformin, Herbal medicine, Combination, Antioxidative, Adipocyte differentiation
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